The yeast PH domain proteins Slm1 and Slm2 are targets of sphingolipid signaling during the response to heat stress.

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P(2)] is a key second messenger that regulates actin and membrane dynamics, as well as other cellular processes. Many of the effects of PtdIns(4,5)P(2) are mediated by binding to effector proteins that contain a pleckstrin homology (PH) domain. Here, we identify two novel effectors of PtdIns(4,5)P(2) in the budding yeast Saccharomyces cerevisiae...

Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae

The PH domain-containing proteins Slm1 and Slm2 were originally identified as substrates of the rapamycin-insensitive TOR complex 2 (TORC2) and as mediators of signaling by the lipid second messenger phosphatidyl-inositol-4,5-bisphosphate (PI4,5P2) in budding yeast S. cerevisiae. More recently, these proteins have been identified as critical effectors that facilitate phosphorylation and activat...

The PH domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind PtdIns(4,5)P2 and TORC2

Feeding Artemia larvae with yeast heat shock proteins 82 (HSPs82) to enhance the resistance against abiotic stresses (hyperosmotic and high temperatures)

Feeding farmed Artemia with yeast heat shock proteins is a novel way to protect them from stress conditions during the culture.  In this study, the effect of feeding with stressed new identified Saccharomyces cerevisiae strain YG3-1 yeasts (containing induced heat shock proteins) on the survival of Artemia in stress conditions, was evaluated. For this purpose, heat shock proteins 82 (Hsps 82) o...

Alternative splicing coupled nonsense-mediated decay generates neuronal cell type-specific expression of SLM proteins.

The unique physiological and morphological properties of neuronal populations are crucial for the appropriate functioning of neuronal circuits. Alternative splicing represents an attractive mechanism for generating cell type-specific molecular repertoires that steer neuronal development and function. However, the mechanisms that link neuronal identity to alternative splicing programs are poorly...